Thyroid and Muscle Loss

Thyroid imbalance and muscle loss in men


  • Many men suffering from low testosterone levels are also experiencing a thyroid disorder of some kind.
  • This could be hypothyroidism, a condition in which your thyroid produces critically low levels of thyroid hormones, or it could simply be because the production of thyroid hormones decreases as you age.
  • An underperforming thyroid can leave you feeling sluggish and unfocused.
  • You may find that you’ve lost the energy to exercise or that you’re losing muscle mass.
  • Muscle loss is a common symptom in men with low thyroid levels because the thyroid is responsible for transporting energy to various parts of the body on a cellular level.
  • A lack of these crucial hormones can lead to muscle weakness, muscle loss, and, in extreme cases, myopathy.
  • Bioidentical hormone replacement therapy replenishes both your thyroid and testosterone levels so you can finally feel like yourself again, regain your energy, and start building back lost muscle mass.
Wondering if you may have a low thyroid level? Take our free hormone assessment to see if you can benefit from Hormone Replacement Therapy. 

Why am I losing muscle mass?

It’s not unusual for muscle mass to decrease as men age, but why does this happen, and how is your thyroid responsible? The thyroid, located at the base of the neck, is largely responsible for energy and metabolism. It releases two crucial hormones, the active T3 (triiodothyronine) and the more inactive T4 (thyroxine), that help transport energy to cells throughout your body and skeletal muscles. Without enough of these hormones, you’ll have difficulty building new muscle through exercise and may lose existing muscle mass.

Studies show [1] that men who are middle-aged and older start to lose muscle strength due to the natural decline of hormone levels. Thyroid hormones, like testosterone, begin to fall as men age. While this is an expected part of aging, it can leave you feeling exhausted, unfocused, and not yourself. The absence of thyroid hormones can also result in hypothyroidism, a condition in which the thyroid produces critically low levels of T3 and T4.

Common symptoms of low thyroid levels in men include:

  • Muscle loss and weakness
  • Difficulty building muscle
  • Aching joints
  • Slow reflexes
  • Fatigue
  • Weight gain
  • Depression and mood swings
  • Lack of focus
  • Low libido
  • Dry skin
  • Brittle hair and nails


Thyroid dysfunction can be relatively hard to diagnose in men, especially since the symptoms of an underactive thyroid closely resemble the symptoms of low testosterone. Even if your thyroid levels aren’t critically low, they can easily fall below the desired level in aging men. A good rule of thumb is to pay attention to your body. If you’re experiencing these symptoms or struggling with muscle loss, you could probably benefit from bioidentical hormone replacement therapy (BHRT).

Start Bioidentical Hormone Replacement Therapy by completing a free hormone assessment and purchasing your at-home lab kit. 

Thyroid hormones and muscle loss

Although the thyroid regulates energy in many areas of your body, studies have found [2] that skeletal muscle is one of the primary targets of T3 signaling. Thyroid hormones control the oxidative metabolism of your cells, meaning their ability to gain and use energy for growth.

When the thyroid releases T3, hormone receptors in your muscles receive these signals, take in energy, and help your body build more muscle. As T3 production decreases, these receptors become unable to produce the same amount of energy, and muscle growth slows.

Another key link between your thyroid and your muscles is an enzyme called Type 2 iodothyronine deiodinase (DIO2) which helps convert the inactive T4 into active T3 that your body can use. Your thyroid produces much more T4 than T3, making conversion necessary for muscle growth and improved energy. The presence of DIO2 is increased in developing muscles [3] and helps them continue to grow, but DIO2 levels are typically low in men with myopathy or muscle loss. Thyroid treatment that exclusively provides T4 is often ineffective because, without these crucial converters, your muscles still aren’t getting a sufficient amount of active thyroid hormones.

Thyroid vs. Testosterone

Muscle loss is also a common symptom in men with low testosterone levels. The overlap between low testosterone and low thyroid occurs because the two depend on one another. Without enough thyroid hormones, testosterone production slows as well, depriving your body of energy and making muscle growth difficult. Through a hormonal chain reaction [4], thyroid hormones signal your body to produce more testosterone.

First, thyroid hormones stimulate the hypothalamus, which produces GnRH (gonadotropin-releasing hormones). These hormones then signal the pituitary gland which produces another key hormone, LH (luteinizing hormone). LH triggers the testes to start making testosterone and the cycle continues.

Your thyroid also produces important proteins called sex hormone-binding globulins (SHBGs), which bind to important sex hormones, like testosterone. SHBGs transport and regulate testosterone, ensuring optimal T levels throughout your body. Without them, you won’t see as many of the positive effects of testosterone production. This is why thyroid supplements are also crucial to seeing results in BHRT treatment.

Testosterone plays a huge role in your body’s muscle protein synthesis [5]; the process of building new muscle and maintaining muscle mass after exercise. Without the help of thyroid hormones, however, you have no way to retain your muscle strength or to use energy to build new muscle mass. You may be experiencing a lack of energy, but if you do feel up to working out, you likely won’t see the results you want without first replenishing your hormones. Not only is it difficult to build more muscle, but it’s also hard for your muscles to recover from the strain of exercise, leaving you vulnerable to muscle and joint pain.

How can BHRT help?

Thyroid dysfunction can occur for many reasons, from autoimmune conditions to simply aging, but if you’re struggling to build muscle or experiencing other energy-related symptoms, replenishing your supply of thyroid hormones can make a difference. You don’t have to wait until your thyroid levels are critically low to seek treatment, either. Many men experience thyroid deficiencies as they age and need to replenish these critical hormones to reach optimal levels and feel good again. With BHRT, you can achieve the optimal hormone levels you had in your youth and finally regain your vitality.

Benefits of thyroid treatment include but are not limited to:

  • Improved energy and sleep
  • Faster metabolism
  • Increased muscle mass
  • Weight loss
  • Better mood
  • More focus and motivation
  • Improved libido


With our at-home hormone test, you can assess your thyroid levels and ensure that you’re getting the optimal amount of thyroid hormones. When creating a treatment tailored to your needs, our US-licensed medical providers carefully consider your symptoms along with your blood test results. If your thyroid levels have you feeling sick, exhausted, and not yourself, BHRT can help give you the boost you need.

Feel energetic and strong with BHRT. It’s time to build back your muscle and feel like yourself again.

Ready to finally see the results you've been looking for? Get started with our free hormone assessment today to start on your HRT journey!

Thyroid Health

Any questions? Schedule a free consult with one of our hormone specialists today!

Frequently asked questions

HRT stands for hormone replacement therapy. Hormone levels are tested and medications are administered to help hormones such as testosterone and thyroid reach their optimum levels.

TRT stands for testosterone replacement therapy. Testosterone is given to combat decreasing levels in men. This is to fight the usual signs and symptoms of aging such as fatigue, weight gain, loss of libido, and muscle loss.

We offer a daily injectable Testosterone Cypionate or a twice-daily Lipoderm cream. Both are bioidentical. We also prescribe Triclozene (Clomiphene Citrate) for men, which can help improve several aspects of male health, including low testosterone levels, hormone ratios and sperm production.

The benefits of HRT are extensive but include the following: healthy heart and blood, less fat, more muscle, stronger bones, improved libido, better sleep, improved memory, spatial ability and mental reasoning, improved mood, and better sex.

You can start your HRT journey by filling out our simple online hormone assessment here.

On average it takes approximately 7 business days from ordering your test kit to receiving your results. This is obviously dependent on how quickly you complete and return the test via free return postage. Once we have received your results, a dedicated medical provider will review this along with your online assessment to create your personalized treatment plan.

This is a very difficult question because there is no definitive answer. Everybody is biologically different and responds to the treatment differently. For detailed information, click here.

The test indicates whether you will benefit from this treatment and what your current hormone levels are. We can then know the proper medication to get your testosterone and thyroid to their optimum levels.

Our blood spot test measures 5 key hormone levels. It offers distinct advantages over traditional testing methods because it eliminates the need for a blood draw – saving patients time and money. Our blood spot test is a simple to use test that is done in the comfort of your own home. It involves a finger prick and 12 drops of blood dropped onto a card. We include free return postage with your test for your convenience.

Yes. HRT is safe when monitored by a licensed medical provider. This is why we require yearly testing and symptoms questionnaires every 2 months.

The treatment is effective for as long as you take it. Once you stop taking HRT your levels will return to the levels they were previously.

You will be charged $99 for the hormone test kit upon your order. Once approved for treatment, you will be charged every other month for your medication. You also will be charged a Medical Membership per month, which allows you to schedule unlimited consultations with your Male Excel medical provider.

What people say

Don't just take our word for it

Mark TRT PATIENT “Since starting HRT, I have lost 25 lbs., lost 4" in my waist,my energy level has increased and my metabolism has really increased. In short, I feel at least 20 years younger!”
John TRT PATIENT “The process was easy. I had some questions but the doctor was excellent and was able to answer them all. The product has worked as advertised, I feel literally a hundred times better! Would recommend Male Excel!”
Jared TRT PATIENT “You guys are awesome, you are helping people get their physical and emotional life back. Always on time with medicine and up to date with follow up. I can't thank your team enough for that!! Keep up the positive work.”
Jeff TRT PATIENT “I was on low T treatment for about a week when I noticed the difference. I have new-found energy, mental clarity and the desire to go out and do things. Over the next few months it has gotten better and better."
Thomas TRT PATIENT “Male Excel has been great to work with and the medications have made a huge difference in my life. Energy levels, sleep, weight loss and sexual stamina. Thank you Male Excel!”
Chris TRT PATIENT “It has only been a couple of weeks but I'm already starting to feel a ton better. Renewed energy and mental clarity has me back to my old self or at least seeing that I can get there. I wouldn't hesitate to recommend Male Excel.”