Thyroid and Weight Loss

How thyroid treatment can help you reach your weight loss goals.

Thyroid hormone replacement and weight loss

Your thyroid plays a vital role in regulating your metabolic rate, controlling functions in your heart, muscles, and digestive system, along with bone maintenance and the development of your brain. It is known as the metabolism regulator and, along with testosterone, has a pivotal role in maintaining healthy body weight.

The thyroid is a butterfly-shaped gland that sits under the larynx in your neck. It secretes hormones into your bloodstream and performs many functions essential to your health. If your thyroid is not performing to its best or the hormones it secretes show low activity, symptoms become apparent.

The symptoms of low thyroid can include:

  1. Fatigue
  2. Low libido
  3. Erectile dysfunction (ED)
  4. High cholesterol and weight gain
  5. Dry skin
  6. Concentration and memory problems
  7. Low blood pressure
  8. Increased, decreased, or irregular heartbeat
  9. Feeling cold
  10. Constipation

 

It is essential to recognize that some symptoms of low thyroid and low testosterone overlap. Diagnosis via symptoms and blood tests are necessary to determine the cause.

Wondering if you may be suffering from low thyroid levels? Take our free assessment to see if you could benefit from Hormone Replacement Therapy!

Low thyroid and low testosterone can cause weight gain

There is a clear relationship between low thyroid and low testosterone levels. If both hormones are at reduced levels, you will develop weight faster, and it will be harder to lose than for people whose hormones are balanced.

There is a chain reaction of events that start in the thyroid and influence testosterone production in your testicles.

  1. The thyroid stimulates the hypothalamus to produce GnRH (gonadotropin-releasing hormone)
  2. GnRH triggers LH (luteinizing hormone) production in the pituitary gland.
  3. LH then travels to your testicles, telling the Leydig cells to produce testosterone.

 

If the thyroid is not producing hormones efficiently (hypothyroidism), then the signals sent to the testicles are weak or non-existent. Therefore, testosterone production will be insufficient. So, you end up with low testosterone levels, and the symptoms such as weight gain start to occur.

The thyroid controls your metabolism

If the thyroid isn’t functioning effectively, the conversion of what you consume into energy slows. Active thyroid hormone (T3) works throughout your body, telling cells how much energy to use and where to distribute it. If this relationship breaks down, excess calories, not used as energy, become fat stored elsewhere in the body. So, thyroid hormones have an essential metabolic effect, increasing metabolism, producing energy, and stimulating weight loss.

TSH, T4, and T3 are the crucial hormones that show how active your thyroid is.

TSH, thyroid-stimulating hormone (produced in the pituitary gland), triggers your thyroid to produce T3 (triiodothyronine) and T4 (thyroxine). These hormones are different versions of the ‘same’ thing altered by the number of iodine molecules attached to each.

Iodine is essential for the production of thyroid hormones. Iodine binds to thyroid hormones acting as a shield, protecting them from breaking down in the body. Thyroid hormones have four receptors that bind with iodine. On T4, iodine binds to four of these receptors; on T3, only three binds to iodine. 

T4 is more ‘heavily’ shielded by iodine, therefore, it lasts longer in the body; however, it is less active and has minimal effect on the body. T3 is only shielded by iodine on 3 ‘sides,’ and can bind to other cells signaling physiological changes. The only problem is that it is short-lived in circulation because it is less protected.

Test your real thyroid levels with our at-home lab kit.

Is low thyroid to blame for weight gain?

A blood test measuring your hormone levels is the only accurate way to determine whether there’s a problem with your thyroid. The majority of doctors only test for primary hypothyroidism (low thyroid), which only shows if the thyroid functions correctly. However, there are three main reasons why the thyroid may exhibit loss of function. This lack of a proper diagnosis can leave many patients unaware that their thyroid is causing any problems. Correctly identifying low thyroid requires tests and a licensed medical provider who knows what symptoms to look for.

There are three main reasons why the thyroid underperforms:
  1. Inadequate production: Standard practice is to check your thyroid using a TSH (thyroid-stimulating hormone) test. TSH increases as thyroid levels go down and vice-versa, so a high TSH reading indicates low thyroid. Doctors using this test assume, therefore, by reading levels of a hormone that stimulates thyroid production, they can gain an insight into actual hormone levels. Unfortunately, many doctors stop here and take things no further. Only about 20 percent of cases of low thyroid are detected this way.
  2. Non-Conversion: The second way doctors can check low thyroid is called non-conversion. Ordinarily, an enzyme called 5′-deiodinase removes an iodine link from T4, converting it into the more useable T3. As people get older, they tend to produce less 5′-deiodinase, so they cannot convert T4 to active T3, leaving them lacking this vital hormone. About 30% of people with low thyroid suffer from non-conversion.
  3. Thyroid Resistance: The rest of the people with low thyroid activity (the other 50%) have thyroid resistance, which means the receptors that bind with T3 are short in numbers or are structurally inadequate. So, their T3 hormones either connect to receptors incorrectly or not at all. There are a few reasons this can happen, such as high insulin or cortisol levels. Interestingly, these people often show normal TSH, T4, and T3 levels yet still have low thyroid symptoms, so doctors often miss this.

Balanced thyroid hormones are necessary for weight loss, being one of the essential hormones associated with metabolism. Studies show it attacks visceral fat, which is the fat around your organs. Many people don’t understand that doctors give you medication to deal with the numbers, the results of blood tests (cholesterol, glucose, hormone levels, etc.). If you still gain more and more weight, fat that is the problem. If you don’t lose the fat, these numbers don’t mean anything. They are just surrogate markers.

How does the thyroid affect testosterone?

Studies show (1) that thyroid function and testosterone are directly linked. When your thyroid isn’t performing effectively (hypothyroidism), it can indirectly lower free testosterone levels. Poor thyroid performance can also reduce sex hormone-binding globulin levels (SHBG), an essential protein that carries testosterone around the body. So, low thyroid has a ‘double whammy’ effect on testosterone by lowering free testosterone and reducing your body’s ability to transport it around your system via SHBG.

Decreased testosterone levels in men with low thyroid are often accompanied by increased abdominal obesity, high cholesterol, and increased blood glucose levels, often leading to type 2 diabetes.

At Male Excel, we look at both thyroid and testosterone levels. Only by balancing both can their true potential as a weight-loss treatment be realized. Primary care doctors will rarely investigate your thyroid health as thoroughly as Male Excel’s specialists. By looking at test results and symptoms in tandem, our US-licensed medical providers can assess your balance and optimize your hormones for a long and healthy future.

Start Hormone Replacement Therapy today by completing our free hormone assessment.

Additional info on thyroid

Frequently asked questions

HRT stands for hormone replacement therapy. Hormone levels are tested and medications are administered to help hormones such as testosterone and thyroid reach their optimum levels.

TRT stands for testosterone replacement therapy. Testosterone is given to combat decreasing levels in men. This is to fight the usual signs and symptoms of aging such as fatigue, weight gain, loss of libido, and muscle loss.

We offer a daily injectable Testosterone Cypionate or a twice-daily Lipoderm cream. Both are bioidentical. We also prescribe Triclozene (Clomiphene Citrate) for men, which can help improve several aspects of male health, including low testosterone levels, hormone ratios and sperm production.

The benefits of HRT are extensive but include the following: healthy heart and blood, less fat, more muscle, stronger bones, improved libido, better sleep, improved memory, spatial ability and mental reasoning, improved mood, and better sex.

You can start your HRT journey by filling out our simple online hormone assessment here.

On average it takes approximately 7 business days from ordering your test kit to receiving your results. This is obviously dependent on how quickly you complete and return the test via free return postage. Once we have received your results, a dedicated medical provider will review this along with your online assessment to create your personalized treatment plan.

This is a very difficult question because there is no definitive answer. Everybody is biologically different and responds to the treatment differently. For detailed information, click here.

The test indicates whether you will benefit from this treatment and what your current hormone levels are. We can then know the proper medication to get your testosterone and thyroid to their optimum levels.

Our blood spot test measures 5 key hormone levels. It offers distinct advantages over traditional testing methods because it eliminates the need for a blood draw – saving patients time and money. Our blood spot test is a simple to use test that is done in the comfort of your own home. It involves a finger prick and 12 drops of blood dropped onto a card. We include free return postage with your test for your convenience.

Yes. HRT is safe when monitored by a licensed medical provider. This is why we require yearly testing and symptoms questionnaires every 2 months.

The treatment is effective for as long as you take it. Once you stop taking HRT your levels will return to the levels they were previously.

You will be charged $99 for the hormone test kit upon your order. Once approved for treatment, you will be charged every other month for your medication. You also will be charged a Medical Membership per month, which allows you to schedule unlimited consultations with your Male Excel medical provider.

What people say

Don't just take our word for it

Mark TRT PATIENT “Since starting HRT, I have lost 25 lbs., lost 4" in my waist,my energy level has increased and my metabolism has really increased. In short, I feel at least 20 years younger!”
John TRT PATIENT “The process was easy. I had some questions but the doctor was excellent and was able to answer them all. The product has worked as advertised, I feel literally a hundred times better! Would recommend Male Excel!”
Jared TRT PATIENT “You guys are awesome, you are helping people get their physical and emotional life back. Always on time with medicine and up to date with follow up. I can't thank your team enough for that!! Keep up the positive work.”
Jeff TRT PATIENT “I was on low T treatment for about a week when I noticed the difference. I have new-found energy, mental clarity and the desire to go out and do things. Over the next few months it has gotten better and better."
Thomas TRT PATIENT “Male Excel has been great to work with and the medications have made a huge difference in my life. Energy levels, sleep, weight loss and sexual stamina. Thank you Male Excel!”
Chris TRT PATIENT “It has only been a couple of weeks but I'm already starting to feel a ton better. Renewed energy and mental clarity has me back to my old self or at least seeing that I can get there. I wouldn't hesitate to recommend Male Excel.”

Studies and References:

The Impact of Testosterone on Metformin Action on Hypothalamic‐Pituitary‐Thyroid Axis Activity in Men: A Pilot Study, Robert Krysiak MD, Ph.D. Witold Szkróbka MD Bogusław Okopień MD, Ph.D. First published: 06 August 2019 https://doi.org/10.1002/jcph.1507

Krytskyy T, Pasyechko N, Yarema N, Naumova L, Mazur L. INFLUENCE OF AGE-RELATED ANDROGEN DEFICIENCY ON THE RISK FACTORS ЕOF CARDIOVASCULAR DISEASES IN MEN WITH HYPOTHYROIDISM. Georgian Med News. 2020 Jan;(298):105-109. PMID: 32141860.

Ford HC, Cooke RR, Keightley EA, Feek CM. Serum levels of free and bound testosterone in hyperthyroidism. Clin Endocrinol (Oxf). 1992 Feb;36(2):187-92. doi: 10.1111/j.1365-2265.1992.tb00956.x. PMID: 1568351.

ADDITIONAL IMPORTANT SAFETY INFORMATION

WARNING: SECONDARY EXPOSURE TO TESTOSTERONE

· See full prescribing information for complete boxed warning
· Virilization has been reported in children with secondary exposure to topical testosterone products
· Children should avoid contact with unwashed or unclothed application sites in men using topical testosterone products
· Healthcare providers should advise patients to strictly adhere to recommended instructions for use

Disclaimer: The information provided on this page is not a substitute for professional medical advice, diagnosis, or treatment. If you have any questions or concerns about your health, please talk to a doctor.

Warnings and Precautions:

· Possible increased risk of heart attack or stroke.
· Male Excel’s testosterone products are not meant for use by women.
· It is not known if Male Excel’s testosterone products are safe or effective in children younger than 18 years old. Improper use of testosterone in children may affect bone growth.
· Testosterone can be abused when taken at higher than prescribed doses and when used with other anabolic androgenic steroids. Male Excel’s Testosterone Lipoderm Cream is a controlled substance (CIII) because it contains testosterone that can be a target for people who abuse prescription medicines. Anabolic androgenic steroid abuse can lead to serious cardiovascular and psychiatric adverse reactions. Your doctor will check you for signs of abuse before and during treatment.
· Keep your Male Excel products in a safe place to protect them.
· Never give your Male Excel products to anyone else, even if they have the same symptoms you have.
· Selling or giving away this medicine may harm others and is against the law.

These are not all the possible side effects. See the Full Prescribing Information for more.

What Should You Know Before Taking Male Excel’s Testosterone Lipoderm Cream?

It is not known if Male Excel’s Testosterone Lipoderm Cream is safe or effective in treating men who have low testosterone due to aging.

It is not known if Male Excel’s Testosterone Lipoderm Cream is safe or effective in children younger than 18 years old.

Male Excel l’s Testosterone Lipoderm Cream is a controlled substance (CIII) because it contains testosterone that can be a target for people who abuse prescription medicines. Keep it in a safe place to protect it, and never give it to anyone else. Selling or giving away this medicine may harm others and is against the law.

Male Excel’s Testosterone Lipoderm Cream is not meant for use in women.

Male Excel’s Testosterone Lipoderm Cream can transfer from your body to others, including children and women. Transference can happen if other people come into contact with the area where Male Excel’s Testosterone Lipoderm Cream is applied. Children and women should avoid contact with the unwashed or uncovered (unclothed) areas where Male Excel’s Testosterone Lipoderm Cream has been applied to your skin.

Early signs and symptoms of puberty have occurred in young children who have come in direct contact with testosterone by touching areas where men have used Male Excel’s Testosterone Lipoderm Cream.

Signs and symptoms of early puberty in a child who has come in direct contact with Male Excel’s Testosterone Lipoderm Cream may include:

· Abnormal sexual changes.
· Enlarged penis or clitoris.
· Early hair growth near the vagina or around the penis (pubic hair).
· Erections or acting out sexual urges (sex drive).
· Behavior problems, including acting aggressively or behaving angrily or violently.

Signs and symptoms in a woman who has come in direct contact with Male Excel’s Testosterone Lipoderm Cream may include:

· Changes in body hair.
· An abnormal increase in pimples (acne).

To lower the risk of transfer of Male Excel’s Testosterone Lipoderm Cream from your body to others, you should follow these important instructions:

· Apply Male Excel’s Testosterone Lipoderm Cream only to areas of your shoulders, upper arms, or stomach area (abdomen) that a short-sleeve t-shirt will cover.
· Wash your hands right away with soap and water after applying testosterone cream
· After the gel has dried, cover the application area with clothing. Keep the area covered until you have washed or showered the application area well.
· If you expect skin-to-skin contact with another person, wash the application area well with soap and water.
· If a child or woman touches the area where you have applied testosterone cream, that area on the child or woman should be washed thoroughly with soap and water immediately.

Stop using Male Excel’s Testosterone Lipoderm Cream and call your healthcare provider immediately if you see any signs and symptoms of puberty in a child or changes in body hair. The same applies if you notice increased acne in a woman that may have happened through accidental touching of the area where you have applied Male Excel’s Testosterone Lipoderm Cream.

Do not use Male Excel’s Testosterone Lipoderm Cream if you:

· Have breast cancer or have or might have prostate cancer.
· Are pregnant. Male Excel’s Testosterone Lipoderm Cream may harm your unborn baby. Pregnant women should avoid contact with the area of skin where Male Excel’s Testosterone Lipoderm Cream has been applied.

Before using Male Excel’s Testosterone Lipoderm Cream, inform your healthcare provider about all of your medical conditions, including if you have breast cancer, prostate cancer, urinary problems due to an enlarged prostate, heart, kidney, or liver problems, or problems breathing while you sleep (sleep apnea).

Inform your healthcare provider of all medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Especially tell your healthcare provider if you take insulin, medicines that decrease blood clotting (blood thinners), or corticosteroids.

Male Excel’s Testosterone Lipoderm Cream can cause serious side effects, including:

· If you already have an enlarged prostate gland, your signs and symptoms can worsen while using Male Excel’s Testosterone Lipoderm Cream (including changes in urination).
· Possible increased risk of prostate cancer.]
· Blood clots in the legs or lungs. Signs and symptoms of a blood clot in your leg can include leg pain, swelling, or redness. Signs and symptoms of a blood clot in your lungs can include difficulty breathing or chest pain.
· Possible increased risk of heart attack or stroke.[sw4]
· In large doses, Male Excel’s Testosterone Lipoderm Cream may lower your sperm count.
· Swelling in your ankles, feet, or body, with or without heart failure. This may cause serious problems for people with heart, kidney, or liver disease.
· Enlarged or painful breasts.
· Having problems breathing while you sleep (sleep apnea).

The most common side effects of Male Excel’s Testosterone Lipoderm Cream include increased prostate-specific antigen (a test used to screen for prostate cancer), mood swings, high blood pressure, increased red blood cell count, acne, and skin irritation where the gel is applied.

This is the most important information to know about Male Excel’s Testosterone Lipoderm Cream. For further information, talk with your healthcare provider.

Tell your healthcare provider if you have any side effect that bothers you or does not go away.

These are not all the possible side effects of Male Excel’s Testosterone Lipoderm Cream. For more information, ask your healthcare provider or pharmacist.

Please click here to see full prescribing information, Medication Guide, and complete boxed warnings for the product.

You are encouraged to report any adverse side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

ADDITIONAL IMPORTANT SAFETY INFORMATION AND BLACK BOX WARNING

WARNING: Drugs with thyroid hormone activity, alone or together with other therapeutic agents, have been used for the treatment of obesity. In euthyroid patients, doses within the range of daily hormonal requirements are ineffective for weight reduction. Larger doses may produce serious or even life-threatening manifestations of toxicity, particularly when given in association with sympathomimetic amines such as those used for their anorectic effects.

What Should You Know Before Taking Male Excel’s desiccated thyroid [tetraiodothyronine sodium (T4 levothyroxine) and triiodothyronine sodium (T3 liothyronine)]?

PLEASE NOTE: The information provided on this page is not a substitute for professional medical advice, diagnosis, or treatment. If you have any questions or concerns about your health, please talk to a doctor.

This is not an Orange Book product and has not been subjected to FDA therapeutic equivalency or other equivalency testing. No representation is made as to generic status or bioequivalency. Each person recommending a prescription substitution using this product shall make such recommendations based on each such person’s professional opinion and knowledge upon evaluating the active ingredients, excipients, inactive ingredients and chemical information provided herein. All prescription substitutions and/or recommendations using this product shall be made subject to state and federal statutes as applicable.

What is Male Excel’s desiccated thyroid?

· Male Excel’s desiccated thyroid is a prescription medicine used to treat a condition called hypothyroidism from any cause, except for cases of temporary hypothyroidism, which is usually associated with an inflammation of the thyroid (thyroiditis). It is meant to replace or supplement a hormone that is usually made by your thyroid gland.

When should I not take Male Excel’s desiccated thyroid?

· Male Excel’s desiccated thyroid should not be used for weight loss. Do not use Male Excel’s desiccated thyroid if you have hyperthyroidism, overactive thyroid, uncorrected adrenal problems, or are allergic to any of its ingredients.

What warnings should I know about Male Excel’s desiccated thyroid?

· Large doses of Male Excel’s desiccated thyroid may cause serious or life-threatening side effects, including chest pain, increased pulse rate, rapid, strong, irregular heartbeat, and excessive sweating.
· Male Excel’s desiccated thyroid should be used with caution in people with heart disease, on diabetes medication, or on blood thinning medication.
· Children may experience partial hair loss in the first few months of thyroid therapy, but this will usually go away on its own.

What should I tell my healthcare provider?

· Tell your doctor immediately if you experience chest pain, increased pulse rate, rapid, strong, irregular heartbeat, excessive sweating, or any other unusual event.
· Tell your doctor about any other medical conditions you may have, especially heart disease, diabetes, blood clotting problems, and adrenal or pituitary gland problems. The dose of other drugs you may be taking to control these conditions may have to be changed while you are taking Male Excel’s desiccated thyroid.
· If you have diabetes, check your blood sugar levels and/or the glucose in your urine, as ordered by your doctor and immediately tell your doctor if there are any changes.
· Tell your doctor if you are allergic to any foods or drugs, are pregnant or plan to become pregnant, are breastfeeding or are taking any other drugs, as well as prescription and over-the-counter products.

What are the side effects of Male Excel’s desiccated thyroid?

· Side effects may include chest pain, increased pulse rate, rapid, strong, irregular heartbeat, or excessive sweating. If you experience these side effects, immediately contact your doctor.

What other medications might interact with Male Excel’s desiccated thyroid?

· Male Excel’s desiccated thyroid can interact with some medications, such as oral anticoagulants, which are medicines used to thin the blood, insulin or oral medications used to treat diabetes, certain medications used to treat high cholesterol levels, and estrogen-containing birth control pills.

IMPORTANT RISK INFORMATION

Thyroid hormones, including Male Excel’s desiccated thyroid, should not be used alone or in combination with other drugs to treat obesity or weight loss. In patients with normal thyroid levels, doses of Male Excel’s desiccated thyroid used daily for hormone replacement are not helpful for weight loss. Larger doses may result in serious or even life-threatening events, especially when combined with certain other drugs used to reduce appetite.

· Male Excel’s desiccated thyroid is contraindicated in patients with uncorrected adrenal insufficiency, untreated thyrotoxicosis, and hypersensitivity to any component of the product.
· In the elderly and patients with cardiovascular disease, Male Excel’s desiccated thyroid should be used with greater caution than younger patients or those without cardiovascular disease.
· Use of Male Excel’s desiccated thyroid in patients with diabetes mellitus or adrenal cortical insufficiency may worsen the intensity of their symptoms.
· The therapy of myxedema coma requires simultaneous administration of glucocorticoids.
· Concomitant use of Male Excel’s desiccated thyroid with oral anticoagulants alters the sensitivity of oral anticoagulants. Prothrombin time should be closely monitored in thyroid-treated patients on oral anticoagulants.
· In infants, excessive doses of Male Excel’s desiccated thyroid may produce craniosynostosis.
· Partial loss of hair may be experienced by children in the first few months of therapy but is usually transient.
· Adverse reactions associated with Male Excel’s desiccated thyroid therapy are primarily those of hyperthyroidism due to therapeutic overdosage.
· Many drugs and some laboratory tests may alter the therapeutic response to Male Excel’s desiccated thyroid. In addition, thyroid hormones and thyroid status have varied effects on the pharmacokinetics and actions of other drugs. Administer at least 4 hours before or after drugs that are known to interfere with absorption. Evaluate the need for dose adjustments when regularly administering within one hour of certain foods that may affect absorption.

Please click here to see full prescribing information, including BOXED WARNING and important safety information.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088