Hormones and Memory Loss in Men
Reduced hormones can cause memory loss in men
Reduced hormones can cause memory loss in men
Bioidentical hormone replacement therapy (BHRT) can help reduce the likelihood of age-related memory loss, dementia, and even Alzheimer’s disease. By balancing hormone levels, men see increases in memory, improved performance at work, and so much more.
Many studies conclude that testosterone replacement therapy (TRT) improves memory and protects the brain from degeneration, as well as reducing the likelihood of developing Alzheimer’s disease.
“Numerous clinical studies in postmenopausal women and men in the andropause showed improvements of learning and memory after testosterone supplementation. Even a short 6-week testosterone treatment resulted in improved spatial and verbal memory of older men” (Cherrier et al., 2001) .
Testosterone, thyroid, and estradiol can all improve cognitive function, including memory, mood, and mental agility. Studies also show that TRT can help avoid and slow Alzheimer’s Disease and age-related dementia. The importance of replacing these hormones is crucial, helping protect your mind against debilitating damage.
Testosterone, thyroid, and estradiol can all improve cognitive function, including; memory, mood, and mental agility. Studies also show that TRT can help avoid and slow Alzheimer’s Disease and age-related dementia. The importance of replacing these hormones is crucial, helping protect your mind against debilitating damage.
Ready to start hormone replacement therapy? Start by taking our free hormone assessment!
As men age, they experience falling hormone levels. From around 30 years old, testosterone levels start to fall 1-2% every year. Hormones affect many aspects of life; weight, sleep patterns, libido, and muscles, but they can also affect memory. Commonly, men with declining testosterone levels experience memory loss and a lack of mental clarity, which many describe as brain fog.
Brain fog manifests itself in many ways including lack of focus, forgetfulness, and distractibility.
Many men experience a similar decline in hormone levels as women experiencing menopause, and many have similar symptoms needing similar treatment.
Wondering if you may be suffering from low hormone levels? Take our free hormone assessment to see if you could benefit from Hormone Replacement Therapy!
Testosterone, thyroid, and estradiol are all essential for memory and mental processing. If you are deficient in any of these hormones or are out of balance, you may experience difficulty concentrating, slower cognitive decision-making, and memory loss.
Testosterone is called a precursor hormone. Testosterone is converted into estradiol (via aromatization) and into Dihydrotestosterone (via an enzyme called 5-alpha-reductase). These two hormones have a significant impact on you your body, particularly estradiol.
Estradiol protects your brain from degeneration against specific proteins known to cause memory loss and even Alzheimer’s disease.
Estradiol (a form of estrogen) increases levels of an enzyme that assists the synthesis of a brain chemical called acetylcholine, which is critical to your memory. Estradiol also improves the interaction between specific neurons in the hippocampus, an area of the brain responsible for verbal memory.
Around 70% of people living with Alzheimer’s are women, who after menopause, experience an almost total loss of estradiol production. This decline displays estradiol’s powerful protective function on the brain. Alzheimer’s is caused by a build-up of amyloid-β and tau proteins in the brain. Research shows that estradiol may help protect the brain by stopping some of these proteins’ harmful effects.
The presence of too many amyloid-β proteins increases the production of damaging free radicals in the brain. Molecules called antioxidants help neutralize these, with estradiol helping reduce free radicals to safer levels. Estradiol suppresses the build-up of toxic free radicals in the brain, which also reduces your risk of having a stroke. Consequently, this is one of the main reasons we don’t prescribe estrogen blockers. Doing so could be damaging to the brain.
Thyroid hormones T4 and T3 also play an essential role in memory and spatial awareness. If the thyroid is underperforming (hypothyroidism) or your body can’t process these hormones effectively, issues can occur. Studies  show that a lack of these hormones can significantly reduce the volume of the right hippocampus; the area of the brain responsible for memory, social behavior, and spatial awareness.
At Male Excel, our trained medical providers know how to recognize the signs of thyroid problems. With the proper tests, we can rebalance all your hormone levels back to optimal, improving memory and brain fog symptoms.
Long-term stress can also affect your brain. When you are in stressful situations, cortisol releases into your body, heightening your senses. If levels are high continuously, it can be damaging to memory can potentially slightly reduce your brain size.
Over time, stress can also increase your risk of other health problems, including high blood pressure, heart disease, obesity, and depression. When you are stressed, cortisol reduces testosterone levels. If your testosterone levels are too low, estradiol levels will fall along with their protective effects on memory. If you can reduce the stress, cortisol will fall, allowing beneficial testosterone and estradiol to normalize.
Testosterone supplementation improves spatial and verbal memory in healthy older men
M.M. Cherrier, S. Asthana, S. Plymate, L. Baker, A.M. Matsumoto, E. Peskind, M.A. Raskind, K. Brodkin, W. Bremner, A. Petrova, S. LaTendresse, S. Craft
Neurology Jul 2001, 57 (1) 80-88; DOI: 10.1212/WNL.57.1.80
Zitzmann M. (2006). Testosterone and the brain. The aging male : the official journal of the International Society for the Study of the Aging Male, 9(4), 195–199. https://doi.org/10.1080/13685530601040679
Cooke GE, Mullally S, Correia N, O’Mara SM, Gibney J. Hippocampal volume is decreased in adults with hypothyroidism. Thyroid. 2014 Mar;24(3):433-40. doi: 10.1089/thy.2013.0058. Epub 2014 Feb 24. PMID: 24205791.