Pros and Cons of Testosterone Creams vs Injections

Which is better, testosterone cream or injections?​


  • One of the most common questions we get is whether the testosterone cream or the injections are best. We firmly believe what is best simply means ‘what is best for you.’
  • There are differences between injections and creams and both have advantages and disadvantages.
  • Men tend to assume that because injections go straight into the muscle, the effects are more powerful and immediate. This is untrue and many men find the cream just as, if not more, effective.
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Topical testosterone lipoderm cream​

Our testosterone creams are custom compounded by our partner pharmacy as specified for each patient’s prescription. On average, our creams have a potency of 200 mg/mL, which is about 10-20 times more potent than standard commercial gels and creams. The cream is applied twice daily; once in the morning and once in the evening (usually 4 hours before bed) to the scrotum or inner thigh. The skin here is thinner than most other body areas, meaning that absorption is quick and effective. Studies show that scrotal administration shows up to eight times more bioavailable testosterone in tests than via skin elsewhere on the body.

The cream has a more positive effect on your good cholesterol levels (HDL) and increases testosterone levels more than injections. This benefit makes the creams an attractive option to those with high cholesterol and those at risk of cardiovascular disease.

The main advantage we see with the cream is that it has to pass through the skin. Testosterone itself is a relatively inactive hormone. In your hair follicles is an enzyme called 5 alpha-reductase that converts testosterone into the more powerful and beneficial dihydrotestosterone (DHT). DHT is about 10-100 times as biologically active as testosterone and offers improved erectile function, more energy, improved muscle gains, and improved weight loss. This conversion ultimately means you need less cream to get the same beneficial effects as injections.

Advantages of testosterone cream

  • Testosterone cream increases DHT, meaning more benefits than testosterone alone. This is because DHT is up to 100 times more potent than testosterone.
  • Our pharmacy compounds the medication to a patient’s requirements.
  • Our lipoderm cream is far more potent than commercially available versions. For example, it is up to 20 times more powerful than AndroGel®.
  • Creams provide very stable levels, mimicking the natural testosterone cycle.
  • Creams have a more positive effect on cholesterol profile (specifically increasing HDL) than injections.

Disadvantages of testosterone cream

  • Variable absorption. However, this is unusual, especially via scrotal administration.
  • Applying cream twice a day makes it easy to forget a dose.
  • Testosterone cream has a transference risk. You must wash your hands, clothes, and bedsheets to ensure non-transference to others. This can be problematic if you have young children that sleep in your bed as well as for your partner. However, with scrotal administration, this is easier to avoid.
  • Testosterone cream carries transferal risk to pregnant women, those wishing to get pregnant, and breastfeeding mothers, so we do not prescribe in these situations.

Testosterone cypionate injections

We supply our patients with a 60-day supply of testosterone cypionate 200 mg/mL. If you are on a higher dose, this supply will not last quite so long, and your doctor will advise if changing the dosage.

Daily injections are far better than weekly or bi-weekly injections when it comes to optimizing your hormones. With less frequent injections, your testosterone level will be sky high on day one, and then the level will fall until your next dose, giving you a rollercoaster effect. Whereas with daily injections, no such peaks and troughs exist, and your levels are constant. This daily dose, much like the cream, follows the natural testosterone cycle.

The idea of daily injections does raise a few patients’ eyebrows, but this is the best way to maintain optimum testosterone levels compared to less frequent injections.

Advantages of testosterone injections

  • Consistent, stable levels of testosterone are achieved.
  • More testosterone turns in estradiol than with creams which is great for weight loss, your heart, and avoiding Alzheimer’s’ disease.
  • The injections are less expensive than the creams, so they suit a lower budget.
  • Unlike other clinics that inject intramuscularly with a huge 1-1.5 inch gauge needle causing pain, we use tiny insulin needles that cause little to no pain (many patients say it feels like a tiny prick and can hardly feel it).

Disadvantages of testosterone injections

  • Although daily injections cause little to no pain, they are not for everyone.
  • Injectable testosterone does not have a positive effect on lipids (cholesterol) like creams do.
  • Getting the testosterone into the insulin syringes can be tricky because of its viscous nature. Warming with a hairdryer is often needed.

So, which one is the best, testosterone cream or cypionate injections?

There is no one size fits all approach to testosterone replacement therapy. Whichever method you choose, both are incredibly effective at optimizing hormone levels. You will end up getting the same physiological benefits with either approach:

  • Increased muscle mass gain
  • Weight loss
  • Cognitive enhancement
  • Greater energy levels
  • Improved sexual function and performance
  • More energy and endurance

Some men do see more benefits with the cream and some with injections. In our experience, the cream carries a bit more punch because it increases DHT levels and helps increase good cholesterol. For many, the cream also means no need to inject, which often seals the deal. Either way, the benefits will speak for themselves.

Start Hormone Replacement Therapy today by completing a free hormone assessment and purchasing your at-home hormone lab kit!

Already on T?

Frequently asked questions

HRT stands for hormone replacement therapy. Hormone levels are tested and medications are administered to help hormones such as testosterone and thyroid reach their optimum levels.

TRT stands for testosterone replacement therapy. Testosterone is given to combat decreasing levels in men. This is to fight the usual signs and symptoms of aging such as fatigue, weight gain, loss of libido, and muscle loss.

We offer a daily injectable Testosterone Cypionate or a twice-daily Lipoderm cream. Both are bioidentical. We also prescribe Triclozene (Clomiphene Citrate) for men, which can help improve several aspects of male health, including low testosterone levels, hormone ratios and sperm production.

The benefits of HRT are extensive but include the following: healthy heart and blood, less fat, more muscle, stronger bones, improved libido, better sleep, improved memory, spatial ability and mental reasoning, improved mood, and better sex.

You can start your HRT journey by filling out our simple online hormone assessment here.

On average it takes approximately 7 business days from ordering your test kit to receiving your results. This is obviously dependent on how quickly you complete and return the test via free return postage. Once we have received your results, a dedicated medical provider will review this along with your online assessment to create your personalized treatment plan.

This is a very difficult question because there is no definitive answer. Everybody is biologically different and responds to the treatment differently. For detailed information, click here.

The test indicates whether you will benefit from this treatment and what your current hormone levels are. We can then know the proper medication to get your testosterone and thyroid to their optimum levels.

Our blood spot test measures 5 key hormone levels. It offers distinct advantages over traditional testing methods because it eliminates the need for a blood draw – saving patients time and money. Our blood spot test is a simple to use test that is done in the comfort of your own home. It involves a finger prick and 12 drops of blood dropped onto a card. We include free return postage with your test for your convenience.

Yes. HRT is safe when monitored by a licensed medical provider. This is why we require yearly testing and symptoms questionnaires every 2 months.

The treatment is effective for as long as you take it. Once you stop taking HRT your levels will return to the levels they were previously.

You will be charged $99 for the hormone test kit upon your order. Once approved for treatment, you will be charged every other month for your medication. You also will be charged a Medical Membership per month, which allows you to schedule unlimited consultations with your Male Excel medical provider.

What people say

Don't just take our word for it

Mark TRT PATIENT “Since starting HRT, I have lost 25 lbs., lost 4" in my waist,my energy level has increased and my metabolism has really increased. In short, I feel at least 20 years younger!”
John TRT PATIENT “The process was easy. I had some questions but the doctor was excellent and was able to answer them all. The product has worked as advertised, I feel literally a hundred times better! Would recommend Male Excel!”
Jared TRT PATIENT “You guys are awesome, you are helping people get their physical and emotional life back. Always on time with medicine and up to date with follow up. I can't thank your team enough for that!! Keep up the positive work.”
Jeff TRT PATIENT “I was on low T treatment for about a week when I noticed the difference. I have new-found energy, mental clarity and the desire to go out and do things. Over the next few months it has gotten better and better."
Thomas TRT PATIENT “Male Excel has been great to work with and the medications have made a huge difference in my life. Energy levels, sleep, weight loss and sexual stamina. Thank you Male Excel!”
Chris TRT PATIENT “It has only been a couple of weeks but I'm already starting to feel a ton better. Renewed energy and mental clarity has me back to my old self or at least seeing that I can get there. I wouldn't hesitate to recommend Male Excel.”